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Peptides


 

Some of the Peptides we offer

CJC-1295 is a 30 amino acid peptide hormone that has shown promising and amazing results as a Growth Hormone Releasing Hormone (GHRH) analog. Research supports that CJC-1295 stimulates HGH secretion and can provide a steady increase of HGH with minimal effect on cortisol and prolactin levels. This means increased protein synthesis thus promoting growth and fat loss simultaneously.

Benefits may include:

  • Increased protein synthesis
  • Promotes lipolysis
  • Improves sleep quality
  • Increased bone density
  • Accelerated injury recovery
  • Improved immune system
  • Increased protein synthesis
  • Increased energy
  • Increased IGF-1
  • Increase in lean body mass

Clinical Reference:

  1. Teichman, Sam L.; Neale, Ann; Lawrence, Betty; Gagnon, Catherine; Castaigne, Jean-Paul; Frohman, Lawrence A. (2006). “Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults”. The Journal of Clinical Endocrinology & Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. ISSN 0021-972X. PMID 16352683.
  2. Ionescu, Madalina; Frohman, Lawrence A. (2006). “Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog”. The Journal of Clinical Endocrinology & Metabolism. 91 (12): 4792–4797. doi:10.1210/jc.2006-1702. ISSN 0021-972X.

Ipamorelin

Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone (GH) releasing activity. Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would affect many biological processes. Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells. Unlike other GH releasing peptides, Ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone.

Benefits may include

  • Promotes lipolysis
  • Increased collagen production
  • Increase in lean body mass
  • Improves sleep quality
  • Increased energy
  • Increased endurance
  • Improved cellular repair
  • Increased IGF-1
  • Counteracts glucocorticoid catabolic effects
  • Less appetite stimulation
  • Less release of cortisol, prolactin and aldosterone

Clinical references

  1. Gobburu, Jogarao V. S.; Agersø, Henrik; Jusko, William J.; Ynddal, Lars (1999).Pharmacokinetic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers”. Pharmaceutical Research. 16 (9): 1412–1416. doi:10.1023/A: 1018955126402. ISSN 0724-8741.
  2. Raun, K; Hansen, B.; Johansen, N.; Thogersen, H; Madsen, K; Ankersen, M; Andersen, P. (1998). “Ipamorelin, the first selective growth hormone secretagogue”. European Journal of Endocrinology. 139 (5): 552–561. doi:10.1530/eje.0.1390552. ISSN 0804-4643.

 

GHK-Cu

GHK-Cu is a tripeptide with the amino acid sequence glycyl-histidyl-lysine. It naturally occurs in human plasma. It has also been found in saliva, and urine. In plasma the level of GHK declines as you age. This decline in the GHK-level coincides with the noticeable decrease in regenerative capacity of an organism. GHK-Cu functions as a complex with copper that stimulates collagen production, accelerates wound healing and contraction, improves the take of transplanted skin, and also possesses anti-inflammatory properties.

Benefits may include:

  • Repairs skin barrier proteins
  • Improved skin elasticity and firmness
  • Reduces hyper-pigmentation and skin spots
  • Stimulates skin collagen
  • Improves overall skin appearance
  • Reduces inflammation
  • Improves wound healing and reduce infections
  • Increases hair growth and follicle size

Clinical references:

  1. L. Pickart, J. H. Freedman, W. J. Loker et al., “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells,” Nature, vol. 288, no. 5792, pp. 715–717, 1980.
  2. D. Downey, W. F. Larrabee Jr., V. Voci, and L. Pickart, “Acceleration of wound healing using glycyl-histidyl-lysine copper (II),” Surgical Forum, vol. 25, pp. 573–575, 1985.
  3. H. Ehrlich, “Stimulation of skin healing in immunosuppressed rats,” in Proceedings of the Symposium on Collagen and Skin Repair, Reims, France, September 1991.

Thymosin Alpha-1

Thymosin Alpha-1 has been known as an excellent immune modulator. Thymosin is a small protein produced naturally by the thymus gland which stimulates the development of disease-fighting T cells. The thymus is an integral part of your immune system, where individual T-cells are made to respond to the millions of bacteria, fungi, or viruses that could invade your body. Commonly prescribed for the treatment for chronic viral diseases, Thymosin Alpha-1 has also been shown to increase innate immunity factors and help fight against harmful autoimmune processes. It is given to help control inflammation associated with chronic diseases, which can cause excess fatigue.

Benefits may include:

  • Modulates immune function and inflammation
  • Improved chronic fatigue
  • Suppresses tumor growth
  • Improved autoimmune function
  • Anti-fungal, anti-bacterial and anti-viral properties
  • Protects against oxidative damage
  • Lyme Disease treatment
  • Increases vaccine effectiveness
  • Helps eliminate unhealthy cells and stop infection or cancer growth

Clinical reference

  1. You J, Zhuang L, Cheng HY, Yan SM, Yu L, Huang JH, Tang BZ, Huang ML, Ma YL, Chongsuvivatwong V, et al. World J Gastroenterol. Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B: 2006 Nov 7; 12(41): 6715-21.
  2. Sherman KE, Sjogren M, Creager RL, Damiano MA, Freeman S, Lewey S, Davis D, Root S, Weber FL, Ishak KG, et al. Hepatology. Combination therapy with thymosin alpha1 and interferon for the treatment of chronic hepatitis C infection: a randomized, placebo-controlled double-blind trial. 1998 Apr; 27(4):1128-35.

BPC-157

BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendons, muscles, nervous system and superior healing of damaged ligaments. 

Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.

Benefits may include:

  • Supports cognitive performance
  • Supports joint health
  • Protects against drug-induced damage
  • Restores the serotogenic transport system
  • Protects dopaminergic system
  • Enhances the GABAergic system
  • Reverse opioid tolerance
  • Accelerated wound healing
  • Ligament healing (knee, rotary)
  • Benefits for ulcers in the stomach
  • Benefits for intestinal damage
  • May help irritable bowel disease
  • May help with urinary incontinence
  • Promotes lipolysis 

Clinical reference: 

  1. Cerovecki, Tomislav; Bojanic, Ivan; Brcic, Luka; Radic, Bozo; Vukoja, Ivan; Seiwerth, Sven; Sikiric, Predrag (September 2010). “Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat”. Journal of Orthopaedic Research. 28 (9): 1155–1161. doi:10.1002/jor.21107. ISSN 1554-527X. PMID 20225319.
  2. “Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response”. PMID 17186181. 

Thymosin Beta-4

Thymosin Beta-4 has been known as an excellent immune modulator. Thymosin is a small protein produced naturally by the thymus gland which stimulates the development of disease-fighting T cells. The thymus is an integral part of your immune system, where individual T-cells are made to respond to the millions of bacteria, fungi, or viruses that could invade your body. 

The main mechanism of action is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which assists in joint, tissue, muscle and ligament repair. 

Thymosin Beta-4 plays a crucial role in protecting, regenerating, and remodeling of injured or damaged tissues. After an injury, Thymosin Beta-4 is released by platelets and numerous other types of cells to protect the most damaged cells and tissues. Some studies show it reduces inflammation and microbial growth.

Benefits may include:

  • Modulates immune function and inflammation
  • Improved chronic fatigue
  • Improved muscle tone
  • Suppresses muscle spasms
  • Improved autoimmune function
  • Antifungal and antibacterial properties
  • Protects against oxidative damage
  • Lyme Disease treatment
  • Improved joint & tissue repair
  • Increase in endurance and strength
  • • Helps prevent the formation of adhesions and fibrous bands in muscles, tendons & ligaments

Clinical reference: 

  1. Gómez-Márquez J, Dosil M, Segade F, Bustelo XR, Pichel JG, Dominguez F, Freire M (Oct 1989). “Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes”. Journal of Immunology. 143 (8): 2740–4. PMID 2677145.
  2. Gondo H, Kudo J, White JW, Barr C, Selvanayagam P, Saunders GF (Dec 1987). “Differential expression of the human thymosinbeta

4 gene in lymphocytes, macrophages, and granulocytes”. Journal of Immunology. 139 (11): 3840–8. PMID 3500230.

PT-141

PT-141 (Bremelanotide) is a synthetic peptide developed from Melanotan 2 (MT-II). PT-141 is used for the treatment of erectile dysfunction or impotence in men and HSDD (hypoactive sexual desire disorder) in women. PT-141 is a peptide that was originally developed as a sunless tanning agent.

 It is a melanocyte-stimulating hormone (MSH) that affects sexual arousal, aiding enhanced libido levels and penile erections. Unlike all PDE5 inhibitors, PT-141 does not target the vascular system. Instead, it acts on the nervous system via activation of neurons in the hypothalamus to increase sexual desire.

Benefits may include

  • HSDD (hypoactive sexual desire disorder) in premenopausal women.
  • Beneficial for low libido (male & female)
  • Increase energy
  • Beneficial for ED (erectile dysfunction)
  • Helps enhance sexual satisfaction
  • Skin pigmentation (sunless tanning agent)

Clinical reference

  1. Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ. 2007;7(11):1137-44. Melanocortins in the treatment of male and female sexual dysfunction.
  2. Rosen RC1, Diamond LE, Earle DC, Shadiack AM, Molinoff PB 2004 Apr;16(2):135-42. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.

Zinc Thymulin

Zinc Thymulin (also known as thymic factor) is a nonapeptide produced by two distinct epithelial populations in the thymus first described by Bach in 1977. Its biological activity and antigenicity depend upon the presence of the metal zinc in the molecule. 

This pharmacologically active metallopeptide induces the differentiation of T-cells and enhances several functions of the various T-cell subsets in normal or partially thymus-deficient recipients. Zinc Thymulin has been used for the treatment of hair loss. 

A recent study indicated that topical treatment with zinc thymulin increased hair growth over 6 months; furthermore, there were no systemic or local side effects from the treatment. The zinc thymulin metallo-peptide optionally also improves endogenous hair pigmentation by stimulating melanogenesis in grey hair.

Benefits may include:

  • Improves hair growth
  • Prevents hair loss
  • Improves endogenous hair pigmentation
  • Treatment for androgenic alopecia
  • Useful for both male and female
  • Can be combined with alternate hair growth protocols

Clinical reference

  1. Meier N, Langan D, Hilbig H, Bodo E, Farjo NP, et al. (2012) Thymic peptides differentially modulate human hair follicle growth. J Invest Dermatol 132: 1516-1519.
  2. Renner D, Schuster D, Heim ME (1986) Experiences using the ‘‘thymu-skin’’ hair cure for the prevention of alopecia in cytostatic treatment. Onkologie 5: 285-286

AOD-9604

AOD9604 (Advanced Obesity Drug) is a synthetic peptide fragment that comprises a modified 15 amino acid region of GH with a tyrosine component to help stabilize the molecule. It was originally developed by Professor Frank Ng at Monash University in Australia, with the intent of finding an anti-obesity drug that had the fat burning effects of human growth hormone (HGH) without the muscle-building effect. 

Similar to GH, AOD9604 aids weight reduction in rodent models of obesity and was originally developed for the treatment of obesity in humans. Additionally, it does not stimulate the production of IGF-1, has positive effects on the differentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study. Its positive effects include promoting the repair of bone and cartilage in cases of osteoarthritis. 

Benefits may include:

  • Promotes lipolysis without affecting blood sugar or tissue growth
  • Prompts fat release from obese fat cells
  • Prevents lipogenesis (fat accumulation)
  • Treatment in osteoarthritis, hypercholesterolemia, bone and cartilage repair – results favored when combined with BPC-157
  • Boosts the body’s metabolism
  • Less appetite stimulation

Clinical reference: 

  1. Heffernan M, et al. “The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice”
  2. Stier H, et al. “Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans” Journal of Endocrinology and Metabolism, North America (2013)
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Phone: 973-309-7874
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